What setup of heroes and ship parts are most effective?

Pair your hero dmg type with the ship parts that compliment them. Generally good is to get 2 ships on offence each with 3 heros of the same dmg type, like burning or drowning and 1 on support, would recommend main ship. The wheel has rng specific dmg type as main stat so if you are going for drowning dmg for example a perfect wheel would be o'the Abyss with %dmg or taking on water as main stat.