Level 10 is particularly hard until you can figure out the correct mix of towers to use.
For this level we pretty much used golem and wizard towers and of course some milita near the exits just in case any enemies got through.
Level 10 - Early phase layout
For the golem towers, we selected the blue special upgrade which was really effective at defeating most enemies, couple that with the red upgrade for the wizard tower and we managed a 100% completion!
The boss who appears during the final wave is very tough, but the golem towers should slow him down sufficiently in conjunction with your heroes.
Level 10 - Final wave layout
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