How can I reach the highest damage per hit in the game?

Class: paladin, equipment: air striker+steelblow armor+steelblow ring

then activate ability (left+left+left+attack or right+right+right+attack)

Class: rogue

Equipment: cthulhu dagger, whisper of death ring and death stalker armor.

You need to activate ability.

Damage: 26k normal 51k headshot

Champion's complect + The Sword of a Thousand Wrongs + the watcher ring. Class: ranger (you have to activate ability)

I managed to get 40k consistently with ability activated (priest). I used a light dragon staff, white pearl ring, and Light spell master suit.

Death stalker- cursed amethyst ring- dead vulture stuff. class- high mage

method: ability followed by charged blast( from final skill of force for skill tree